Recently, a new study published in Nature - Communications showed that bioengineered blood vessels that replace the pulmonary artery can grow in the recipient in three lambs. If proven in humans, the new vascular graft will keep young patients from having to undergo repeated surgery. One of the biggest challenges in bioengineering synthetic blood vessels is that the designed blood vessels can change shape after transplantation and co-grow with their new receptors without being rejected by the immune system. Scientists have been working to develop ways to produce such blood vessels, but they need to be carefully prepared using the patient's own cells, long processes, and need to be cultured in the laboratory prior to transplantation. Robert Tranquillo of the University of Minnesota, USA, and colleagues developed blood vessels that fit into storage and are transplanted when needed, without the need to train individual bespoke vessels in the lab. The way they make such artificial blood vessels is to put sheep skin cells in a special tube and regularly push the nutrients needed for cell growth. Regular push can help cells store proteins around them, making the vessels produce the proper mechanical properties. Sheep cells are eventually flushed out leaving only "non-cellular" protein scaffolds that do not elicit an immune response. In fact, when these newly formed acellular vascular grafts replace part of the pulmonary arteries of three lambs, the lamb's own cells quickly fill the transplanted blood vessels, deform the blood vessels and co-grow with the recipient until adulthood. The researchers did not observe adverse reactions, such as coagulation, vascular narrowing or calcification. Although the results of this proof-of-concept study are encouraging, further research, including larger-scale animal studies, is needed before it can be determined that the method is effective and safe for human testing. Silicone Resins, Resin Material, 9003-01-4 Water Based Resin, Coating With Resin,Water Based Epoxy Guangzhou Quanxu Technology Co Ltd , https://www.silicamattingagent.comWater-based resin refers to a type of adhesive or sealant that is made from a combination of water and a polymer base. These resins are commonly used in various industries due to their eco-friendliness, ease of application, and cost-effectiveness.
Here are some key points about water-based resins:
1. Environmental Benefits: Water-based resins have lower volatile organic compound (VOC) emissions compared to solvent-based resins, making them more environmentally friendly. This makes them a popular choice for applications where reducing the environmental impact is a priority.
2. Versatility: They can be used in a wide range of applications including woodworking, furniture making, construction, automotive, and even in the production of composite materials. They can also be formulated to provide different properties such as flexibility, strength, or resistance to heat, chemicals, and UV light.
3. Ease of Use: Water-based resins are generally easier to apply than solvent-based ones because they do not require special equipment or protective clothing. They can often be cleaned up with water rather than harsh solvents.
4. Curing Process: These resins cure through a process called cross-linking, which involves chemical reactions between the components to form a solid material. The curing time can vary depending on factors like temperature, humidity, and the specific formulation of the resin.
5. Disadvantages: While water-based resins offer many benefits, they may not provide the same level of durability and resistance as solvent-based resins. They might also have slower drying times and may not perform well under extreme temperatures or in high-moisture environments.
6. Types: There are various types of water-based resins including acrylic, polyurethane, epoxy, and alkyd resins, each with its own set of properties and uses.
7. Safety: They are typically less hazardous than solvent-based resins, but users should still follow proper safety guidelines when handling them, especially during the mixing and application phases.
8. Application: Water-based resins can be applied using a variety of methods including spraying, brushing, or rolling, depending on the specific application and the desired finish.
When choosing a water-based resin, it's important to consider the specific requirements of your project, including the intended use, environmental considerations, and any necessary performance characteristics.
